Setting description

Hormone_therapies more effective in all the biomarker signatures

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 272 0 0 0
TP53- & AR- 366 2 1 1
TP53+ 235 0 0 1
DRD+ 100 1 0 0
TEfus+ 161 0 0 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.544 0.000 0.000 0.000
TP53- & AR- 0.732 0.004 0.002 0.002
TP53+ 0.470 0.000 0.000 0.002
DRD+ 0.200 0.002 0.000 0.000
TEfus+ 0.322 0.000 0.000 0.004
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 96 70 77
TP53- & AR- 1 383 396 402
TP53+ 0 263 231 225
DRD+ 0 137 199 182
TEfus+ 0 224 203 231
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.192 0.140 0.154
TP53- & AR- 0.002 0.766 0.792 0.804
TP53+ 0.000 0.526 0.462 0.450
DRD+ 0.000 0.274 0.398 0.364
TEfus+ 0.000 0.448 0.406 0.462
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 18 16 24 10
TP53+ 72 12 27 19
DRD+ 0 0 0 0
TEfus+ 0 0 0 1
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.036 0.032 0.048 0.020
TP53+ 0.144 0.024 0.054 0.038
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000 0.002


Errors & power

The overall error was 0.448.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.442             0.006             0.002             0.008 

The overall power was 0.544.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.544             0.000             0.000             0.000 

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 272 0 0 0
futility 0 0 96 70 77
max_n 0 0 0 0 0
n 434 (366, 478) 132 (34, 264) 148 (93, 236) 154 (97, 249) 156 (94, 231)
n_unique 408 (343, 449) 125 (32, 249) 137 (86, 225) 144 (90, 236) 145 (88, 215)
time_trial 36 (36, 36) 32 (5, 36) 36 (29, 36) 36 (33, 36) 36 (32, 36)
time_stop NA (NA, NA) 10 (4, 30) 28 (17, 35) 30 (20, 35) 30 (20, 35)
post_p NA (NA, NA) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.073 (0.067, 0.079) 0.038 (0.032, 0.045) 0.114 (0.102, 0.129) 0.114 (0.101, 0.13) 0.113 (0.101, 0.127)
TP53- & AR- graduation 0 366 2 1 1
futility 0 1 383 396 402
max_n 0 18 16 24 10
n 173 (107, 204) 32 (19, 132) 39 (25, 120) 44 (25, 124) 42 (25, 115)
n_unique 162 (97, 192) 30 (18, 125) 35 (23, 114) 42 (23, 121) 39 (24, 109)
time_trial 36 (36, 36) 12 (7, 36) 23 (14, 36) 23 (13, 36) 22 (13, 36)
time_stop NA (NA, NA) 9 (6, 25) 21 (13, 31) 20 (13, 31) 19 (13, 32)
post_p NA (NA, NA) 1 (0.95, 1) 0.01 (0, 0.09) 0.01 (0, 0.1) 0.01 (0, 0.11)
rate 0.072 (0.063, 0.083) 0.039 (0.03, 0.05) 0.117 (0.098, 0.149) 0.116 (0.096, 0.147) 0.115 (0.095, 0.146)
TP53+ graduation 0 235 0 0 1
futility 0 0 263 231 225
max_n 0 72 12 27 19
n 202 (177, 225) 48 (13, 152) 67 (32, 129) 70 (34, 135) 70 (33, 134)
n_unique 189 (165, 210) 45 (12, 142) 62 (31, 120) 64 (31, 130) 65 (31, 124)
time_trial 36 (36, 36) 36 (10, 36) 35 (15, 36) 36 (19, 36) 36 (17, 36)
time_stop NA (NA, NA) 13 (9, 32) 24 (12, 33) 26 (14, 34) 24 (14, 34)
post_p NA (NA, NA) 1 (0.97, 1) 0 (0, 0.07) 0 (0, 0.07) 0.01 (0, 0.07)
rate 0.073 (0.064, 0.082) 0.038 (0.029, 0.047) 0.115 (0.096, 0.141) 0.115 (0.097, 0.14) 0.113 (0.097, 0.137)
DRD+ graduation 0 100 1 0 0
futility 0 0 137 199 182
max_n 0 0 0 0 0
n 113 (91, 134) 26 (2, 56) 42 (25, 71) 53 (31, 81) 53 (32, 79)
n_unique 105 (86, 125) 24 (1, 53) 39 (22, 67) 48 (29, 75) 50 (30, 74)
time_trial 36 (36, 36) 36 (24, 36) 36 (26, 36) 36 (21, 36) 36 (21, 36)
time_stop NA (NA, NA) 24 (17, 33) 27 (20, 34) 25 (17, 34) 26 (16, 34)
post_p NA (NA, NA) 0.99 (0.77, 1) 0.03 (0, 0.19) 0.02 (0, 0.14) 0.01 (0, 0.14)
rate 0.073 (0.062, 0.085) 0.037 (0.024, 0.054) 0.115 (0.093, 0.151) 0.115 (0.097, 0.142) 0.116 (0.097, 0.142)
TEfus+ graduation 0 161 0 0 2
futility 0 0 224 203 231
max_n 0 0 0 0 1
n 154 (131, 179) 38 (8, 95) 59 (32, 104) 63 (33, 104) 60 (30, 98)
n_unique 144 (121, 167) 35 (7, 89) 55 (29, 97) 58 (31, 95) 56 (29, 91)
time_trial 36 (36, 36) 36 (15, 36) 36 (17, 36) 36 (21, 36) 36 (20, 36)
time_stop NA (NA, NA) 19 (11, 33) 23 (15, 33) 26 (15, 33) 26 (16, 34)
post_p NA (NA, NA) 1 (0.92, 1) 0.01 (0, 0.1) 0.01 (0, 0.11) 0.01 (0, 0.09)
rate 0.072 (0.064, 0.082) 0.039 (0.028, 0.049) 0.114 (0.095, 0.141) 0.114 (0.096, 0.142) 0.115 (0.095, 0.142)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 465 401 404 407
futility 0 0 0 0 0
max_n 0 18 16 24 10
n 111 (69, 134) 25 (15, 100) 21 (9, 77) 23 (8, 80) 20 (8, 74)
n_unique 104 (62, 127) 24 (15, 95) 19 (8, 74) 21 (8, 77) 19 (7, 73)
post_p NA (NA, NA) 1 (0.88, 1) 0.06 (0, 0.23) 0.06 (0, 0.27) 0.07 (0.01, 0.3)
rate 0.072 (0.061, 0.085) 0.039 (0.029, 0.054) 0.119 (0.094, 0.181) 0.118 (0.091, 0.166) 0.117 (0.089, 0.174)
—+ graduation 0 472 423 418 432
futility 0 0 0 0 0
max_n 0 18 16 23 11
n 19 (10, 28) 4 (1, 13) 7 (2, 18) 6 (2, 18) 6 (2, 15)
n_unique 17 (9, 26) 4 (1, 11) 6 (2, 17) 5 (2, 17) 5 (2, 15)
post_p NA (NA, NA) 0.85 (0.51, 0.98) 0.27 (0.1, 0.53) 0.29 (0.12, 0.61) 0.29 (0.12, 0.57)
rate 0.073 (0.049, 0.105) 0.037 (0.013, 0.086) 0.121 (0.082, 0.272) 0.123 (0.072, 0.319) 0.122 (0.073, 0.371)
–+- graduation 0 371 269 234 228
futility 0 0 0 0 0
max_n 0 70 12 27 19
n 71 (57, 83) 22 (7, 68) 14 (5, 52) 16 (5, 53) 15 (5, 52)
n_unique 67 (54, 78) 21 (7, 64) 13 (5, 49) 14 (5, 50) 14 (5, 50)
post_p NA (NA, NA) 0.99 (0.83, 1) 0.12 (0.03, 0.37) 0.12 (0.02, 0.36) 0.14 (0.02, 0.38)
rate 0.074 (0.06, 0.09) 0.038 (0.026, 0.053) 0.12 (0.087, 0.219) 0.121 (0.089, 0.223) 0.118 (0.086, 0.21)
–++ graduation 0 405 338 308 314
futility 0 0 0 0 0
max_n 0 67 12 26 18
n 46 (34, 57) 10 (2, 37) 14 (6, 37) 13 (4, 36) 11 (4, 33)
n_unique 43 (31, 53) 10 (2, 35) 12 (6, 35) 12 (3, 35) 10 (3, 31)
post_p NA (NA, NA) 0.94 (0.57, 1) 0.14 (0.03, 0.45) 0.16 (0.03, 0.44) 0.18 (0.04, 0.5)
rate 0.073 (0.056, 0.093) 0.04 (0.022, 0.07) 0.118 (0.086, 0.2) 0.121 (0.086, 0.242) 0.12 (0.081, 0.258)
-+– graduation 0 472 415 418 415
futility 0 0 0 0 0
max_n 0 18 16 24 10
n 19 (10, 26) 2 (0, 10) 6 (2, 17) 7 (3, 20) 8 (3, 18)
n_unique 17 (9, 25) 1 (0, 9) 5 (1, 15) 7 (2, 19) 7 (3, 17)
post_p NA (NA, NA) 0.8 (0.49, 0.97) 0.27 (0.1, 0.57) 0.28 (0.1, 0.58) 0.27 (0.09, 0.55)
rate 0.076 (0.051, 0.108) 0.037 (0, 0.097) 0.137 (0.077, 0.405) 0.126 (0.082, 0.32) 0.125 (0.082, 0.249)
-+-+ graduation 0 478 435 429 438
futility 0 0 0 0 0
max_n 0 18 16 23 11
n 18 (11, 26) 2 (0, 7) 6 (2, 17) 7 (2, 18) 7 (3, 17)
n_unique 17 (10, 25) 1 (0, 7) 5 (1, 16) 6 (2, 17) 7 (2, 16)
post_p NA (NA, NA) 0.78 (0.42, 0.95) 0.3 (0.11, 0.6) 0.26 (0.08, 0.57) 0.26 (0.1, 0.54)
rate 0.072 (0.049, 0.107) 0.041 (0, 0.135) 0.127 (0.075, 0.343) 0.128 (0.084, 0.303) 0.125 (0.082, 0.289)
-++- graduation 0 392 296 294 276
futility 0 0 0 0 0
max_n 0 70 12 27 18
n 12 (7, 18) 2 (0, 9) 4 (1, 11) 5 (2, 12) 5 (2, 12)
n_unique 12 (7, 17) 2 (0, 8) 4 (1, 10) 5 (2, 11) 5 (2, 11)
post_p NA (NA, NA) 0.77 (0.41, 0.96) 0.34 (0.16, 0.62) 0.32 (0.15, 0.63) 0.32 (0.14, 0.62)
rate 0.074 (0.047, 0.121) 0.043 (0, 0.134) 0.131 (0.069, 0.402) 0.126 (0.073, 0.33) 0.129 (0.071, 0.359)
-+++ graduation 0 415 352 343 346
futility 0 0 0 0 0
max_n 0 67 12 26 17
n 12 (8, 17) 2 (0, 9) 4 (1, 11) 5 (1, 12) 5 (2, 12)
n_unique 12 (7, 16) 2 (0, 8) 3 (1, 10) 5 (1, 12) 5 (2, 11)
post_p NA (NA, NA) 0.77 (0.4, 0.94) 0.34 (0.17, 0.6) 0.32 (0.13, 0.61) 0.3 (0.14, 0.58)
rate 0.072 (0.046, 0.112) 0.043 (0.004, 0.142) 0.134 (0.067, 0.468) 0.135 (0.071, 0.361) 0.134 (0.073, 0.409)
+— graduation 0 272 96 70 77
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 22 (15, 28) 9 (1, 24) 8 (3, 19) 6 (2, 17) 6 (2, 16)
n_unique 21 (14, 27) 8 (1, 22) 8 (3, 18) 6 (2, 16) 6 (2, 15)
post_p NA (NA, NA) 0.86 (0.47, 0.99) 0.23 (0.09, 0.54) 0.27 (0.1, 0.57) 0.28 (0.11, 0.59)
rate 0.074 (0.05, 0.105) 0.041 (0.018, 0.085) 0.124 (0.08, 0.252) 0.131 (0.074, 0.355) 0.123 (0.071, 0.285)
+–+ graduation 0 342 230 210 234
futility 0 0 0 0 0
max_n 0 0 0 0 1
n 17 (11, 23) 5 (1, 17) 7 (3, 15) 6 (2, 14) 5 (2, 15)
n_unique 16 (10, 22) 4 (0, 15) 6 (2, 14) 5 (2, 13) 4 (2, 14)
post_p NA (NA, NA) 0.81 (0.46, 0.98) 0.27 (0.1, 0.57) 0.31 (0.13, 0.62) 0.3 (0.13, 0.58)
rate 0.073 (0.049, 0.11) 0.042 (0.017, 0.095) 0.126 (0.075, 0.288) 0.124 (0.067, 0.332) 0.128 (0.075, 0.411)
+-+- graduation 0 371 269 234 228
futility 0 0 0 0 0
max_n 0 70 12 27 19
n 17 (11, 24) 3 (0, 14) 6 (2, 15) 6 (2, 15) 6 (2, 16)
n_unique 16 (11, 22) 3 (0, 13) 6 (2, 15) 5 (2, 15) 6 (1, 15)
post_p NA (NA, NA) 0.8 (0.45, 0.97) 0.25 (0.1, 0.57) 0.31 (0.13, 0.57) 0.3 (0.12, 0.61)
rate 0.073 (0.046, 0.108) 0.04 (0.012, 0.098) 0.134 (0.082, 0.351) 0.122 (0.074, 0.351) 0.126 (0.069, 0.354)
+-++ graduation 0 405 338 308 314
futility 0 0 0 0 0
max_n 0 67 12 26 18
n 17 (11, 23) 3 (0, 14) 6 (2, 15) 6 (2, 14) 6 (2, 15)
n_unique 15 (10, 22) 3 (0, 14) 6 (2, 15) 5 (1, 13) 5 (1, 14)
post_p NA (NA, NA) 0.82 (0.47, 0.97) 0.28 (0.1, 0.57) 0.29 (0.13, 0.59) 0.31 (0.12, 0.61)
rate 0.073 (0.05, 0.109) 0.038 (0.014, 0.097) 0.125 (0.078, 0.288) 0.127 (0.072, 0.298) 0.126 (0.072, 0.339)
++– graduation 0 319 169 206 182
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 13 (8, 18) 3 (0, 12) 4 (1, 11) 5 (2, 12) 5 (2, 12)
n_unique 12 (7, 17) 3 (0, 12) 4 (1, 10) 4 (2, 11) 5 (2, 11)
post_p NA (NA, NA) 0.83 (0.46, 0.98) 0.35 (0.15, 0.64) 0.3 (0.13, 0.6) 0.3 (0.13, 0.62)
rate 0.078 (0.045, 0.128) 0.036 (0.011, 0.113) 0.131 (0.067, 0.409) 0.139 (0.078, 0.371) 0.135 (0.075, 0.371)
++-+ graduation 0 370 276 286 298
futility 0 0 0 0 0
max_n 0 0 0 0 1
n 12 (8, 18) 2 (0, 10) 4 (1, 11) 5 (2, 13) 5 (2, 12)
n_unique 12 (7, 17) 2 (0, 9) 4 (1, 10) 5 (2, 12) 5 (2, 11)
post_p NA (NA, NA) 0.8 (0.44, 0.96) 0.34 (0.16, 0.63) 0.29 (0.11, 0.61) 0.3 (0.13, 0.61)
rate 0.074 (0.044, 0.12) 0.04 (0.009, 0.108) 0.133 (0.072, 0.401) 0.128 (0.076, 0.367) 0.134 (0.076, 0.352)
+++- graduation 0 392 296 294 276
futility 0 0 0 0 0
max_n 0 70 12 27 18
n 12 (7, 18) 2 (0, 10) 4 (1, 10) 5 (2, 12) 5 (2, 13)
n_unique 12 (6, 17) 2 (0, 9) 3 (1, 10) 5 (2, 11) 4 (2, 11)
post_p NA (NA, NA) 0.77 (0.42, 0.96) 0.33 (0.16, 0.62) 0.33 (0.14, 0.61) 0.3 (0.14, 0.61)
rate 0.072 (0.044, 0.12) 0.039 (0.01, 0.112) 0.133 (0.069, 0.512) 0.129 (0.073, 0.32) 0.133 (0.073, 0.41)
++++ graduation 0 415 352 343 346
futility 0 0 0 0 0
max_n 0 67 12 26 17
n 12 (7, 18) 2 (0, 8) 4 (1, 11) 5 (2, 12) 5 (2, 12)
n_unique 12 (7, 17) 2 (0, 8) 3 (1, 10) 5 (1, 12) 5 (2, 12)
post_p NA (NA, NA) 0.78 (0.41, 0.95) 0.34 (0.15, 0.63) 0.33 (0.13, 0.62) 0.32 (0.14, 0.62)
rate 0.072 (0.045, 0.121) 0.042 (0, 0.122) 0.133 (0.068, 0.458) 0.127 (0.075, 0.378) 0.128 (0.073, 0.318)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 272
time_stop 10 (4, 30)
n_trt 70 (30, 204)
n_control 110 (46, 360)
post_p 1 (0.93, 1)
order 2 (1, 3)
TP53- & AR- count 366 2 1 1
time_stop 9 (6, 26) 10 (9, 12) 12 (12, 12) 13 (13, 13)
n_trt 33 (26, 106) 29 (29, 29) 30 (30, 30) 26 (26, 26)
n_control 41 (27, 118) 35 (34, 36) 57 (57, 57) 59 (59, 59)
post_p 0.96 (0.88, 1) 0.94 (0.9, 0.97) 0.9 (0.9, 0.9) 0.88 (0.88, 0.88)
order 1 (1, 2) 2 (2, 2) 3 (3, 3) 2 (2, 2)
TP53+ count 235 1
time_stop 13 (9, 32) 9 (9, 9)
n_trt 43 (27, 126) 25 (25, 25)
n_control 64 (36, 174) 37 (37, 37)
post_p 1 (0.94, 1) 0.96 (0.96, 0.96)
order 2 (1, 4) 1 (1, 1)
DRD+ count 100 1
time_stop 24 (17, 33) 19 (19, 19)
n_trt 30 (25, 51) 28 (28, 28)
n_control 74 (47, 110) 48 (48, 48)
post_p 0.99 (0.95, 1) 0.98 (0.98, 0.98)
order 3 (1.9, 5) 3 (3, 3)
TEfus+ count 161 2
time_stop 19 (11, 33) 13 (11, 15)
n_trt 38 (26, 83) 30 (27, 33)
n_control 74 (42, 144) 48 (38, 58)
post_p 1 (0.96, 1) 0.9 (0.87, 0.93)
order 3 (2, 5) 1.5 (1.1, 1.9)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 96 70 77
time_stop 28 (17, 35) 30 (20, 35) 30 (20, 35)
n_trt 102 (70, 169) 110 (74, 175) 111 (76, 186)
n_control 334 (190, 418) 348 (238, 435) 346 (247, 436)
post_p 0 (0, 0) 0 (0, 0) 0 (0, 0)
order 6 (2, 9) 6 (3, 10) 6 (3, 10)
TP53- & AR- count 1 383 396 402
time_stop 6 (6, 6) 21 (13, 31) 20 (13, 31) 19 (13, 32)
n_trt 26 (26, 26) 35 (25, 92) 37 (25, 102) 36 (25, 85)
n_control 26 (26, 26) 104 (60, 166) 101 (58, 162) 97 (57, 165)
post_p 0.27 (0.27, 0.27) 0.04 (0, 0.18) 0.05 (0, 0.21) 0.06 (0, 0.2)
order 1 (1, 1) 3 (1, 6) 3 (1, 6) 3 (1, 6)
TP53+ count 263 231 225
time_stop 24 (12, 33) 26 (14, 34) 24 (14, 34)
n_trt 49 (27, 97) 54 (27, 105) 48 (28, 100)
n_control 122 (53, 191) 140 (70, 191) 129 (64, 193)
post_p 0.01 (0, 0.07) 0.01 (0, 0.07) 0.01 (0, 0.06)
order 4 (1, 8) 5 (1, 8) 3 (1, 8)
DRD+ count 137 199 182
time_stop 27 (20, 34) 25 (17, 34) 26 (16, 34)
n_trt 34 (26, 56) 42 (28, 65) 40 (27, 64)
n_control 86 (59, 114) 81 (50, 113) 80 (47, 111)
post_p 0.01 (0, 0.06) 0.01 (0, 0.05) 0.01 (0, 0.06)
order 6 (3, 9) 5 (2, 8.2) 5 (2, 8)
TEfus+ count 224 203 231
time_stop 23 (15, 33) 26 (15, 33) 26 (16, 34)
n_trt 45 (27, 81) 47 (29, 80) 45 (27, 78)
n_control 102 (55, 149) 111 (56, 150) 113 (63, 153)
post_p 0.01 (0, 0.07) 0.01 (0, 0.06) 0.01 (0, 0.05)
order 4 (1, 9) 5 (2, 9) 5 (2, 8)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 272 272 272 272 272 272 272 272 272 272 272 272 272 272 272 272
time 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30) 10 (4, 30)
n 22 (13, 55) 3 (1, 8) 13 (5, 43) 6 (1, 24) 1 (0, 5) 1 (0, 5) 1 (0, 6) 1 (0, 5) 4 (0, 14) 2 (0, 9) 2 (0, 8) 2 (0, 8) 1 (0, 7) 1 (0, 6) 1 (0, 6) 1 (0, 5)
post_p 0.91 (0.64, 1) 0.7 (0.53, 0.9) 0.84 (0.6, 1) 0.72 (0.53, 0.98) 0.62 (0.52, 0.9) 0.64 (0.51, 0.88) 0.62 (0.52, 0.91) 0.68 (0.52, 0.89) 0.66 (0.52, 0.91) 0.62 (0.52, 0.93) 0.65 (0.52, 0.92) 0.64 (0.53, 0.91) 0.62 (0.52, 0.93) 0.63 (0.52, 0.91) 0.66 (0.52, 0.88) 0.64 (0.53, 0.88)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.036 (0, 0.057) 0.01 (0, 0.073) 0.033 (0, 0.058) 0.024 (0, 0.066) 0 (0, 0.07) 0 (0, 0.076) 0 (0, 0.071) 0 (0, 0.072) 0.013 (0, 0.074) 0 (0, 0.072) 0 (0, 0.078) 0 (0, 0.064) 0 (0, 0.075) 0 (0, 0.079) 0.014 (0, 0.078) 0 (0, 0.07)
TP53- & AR- count 366 366 366 366
time 9 (6, 26) 9 (6, 26) 9 (6, 26) 9 (6, 26)
n 26 (20, 74) 4 (2, 11) 2 (0, 9) 2 (0, 6)
post_p 0.9 (0.75, 1) 0.71 (0.54, 0.87) 0.61 (0.52, 0.85) 0.61 (0.51, 0.83)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.035 (0.016, 0.055) 0.024 (0, 0.074) 0 (0, 0.062) 0 (0, 0.072)
Taxel_therapies count 2 2 2 2
time 10 (9, 12) 10 (9, 12) 10 (9, 12) 10 (9, 12)
n 20 (18, 21) 4 (4, 5) 2 (2, 2) 3 (2, 4)
post_p 0.79 (0.72, 0.86) 0.65 (0.61, 0.69) 0.6 (0.52, 0.68) 0.74 (0.74, 0.74)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.038 (0.024, 0.052) 0.067 (0.055, 0.08) 0.044 (0.009, 0.079) 0 (0, 0)
Carboplatin count 1 1 1 1
time 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12)
n 14 (14, 14) 3 (3, 3) 3 (3, 3) 10 (10, 10)
post_p 0.71 (0.71, 0.71) 0.62 (0.62, 0.62) 0.56 (0.56, 0.56) 0.8 (0.8, 0.8)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.029 (0.029, 0.029) 0 (0, 0) 0.063 (0.063, 0.063) 0.032 (0.032, 0.032)
Niraparib count 1 1 1 1
time 13 (13, 13) 13 (13, 13) 13 (13, 13) 13 (13, 13)
n 10 (10, 10) 3 (3, 3) 4 (4, 4) 9 (9, 9)
post_p 0.72 (0.72, 0.72) 0.56 (0.56, 0.56) 0.56 (0.56, 0.56) 0.84 (0.84, 0.84)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.041 (0.041, 0.041) 0 (0, 0) 0.08 (0.08, 0.08) 0.036 (0.036, 0.036)
TP53+ Hormone_therapies count 235 235 235 235 235 235 235 235
time 13 (9, 32) 13 (9, 32) 13 (9, 32) 13 (9, 32) 13 (9, 32) 13 (9, 32) 13 (9, 32) 13 (9, 32)
n 20 (12, 53) 10 (4, 28) 2 (0, 6) 2 (0, 6) 3 (0, 10) 3 (1, 11) 2 (0, 6) 2 (0, 6)
post_p 0.91 (0.75, 1) 0.83 (0.61, 0.99) 0.62 (0.52, 0.87) 0.66 (0.52, 0.87) 0.7 (0.52, 0.93) 0.72 (0.53, 0.91) 0.65 (0.52, 0.9) 0.63 (0.53, 0.87)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.035 (0.013, 0.056) 0.033 (0, 0.063) 0 (0, 0.075) 0 (0, 0.071) 0.02 (0, 0.078) 0.018 (0, 0.064) 0 (0, 0.065) 0 (0, 0.078)
Niraparib count 1 1 1 1 1 1 1 1
time 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9)
n 5 (5, 5) 4 (4, 4) 4 (4, 4) 4 (4, 4) 4 (4, 4) 2 (2, 2) 0 (0, 0) 2 (2, 2)
post_p 0.74 (0.74, 0.74) 0.64 (0.64, 0.64) 0.65 (0.65, 0.65) 0.74 (0.74, 0.74) 0.61 (0.61, 0.61) 0.57 (0.57, 0.57) NA (NA, NA) 0.63 (0.63, 0.63)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.053 (0.053, 0.053) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0)
DRD+ Hormone_therapies count 100 100 100 100 100 100 100 100
time 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33)
n 3 (1, 11) 3 (0, 12) 4 (1, 9) 3 (0, 8) 4 (1, 10) 4 (2, 9) 3 (1, 10) 3 (0, 8)
post_p 0.76 (0.62, 0.94) 0.78 (0.59, 0.92) 0.73 (0.55, 0.94) 0.71 (0.53, 0.9) 0.72 (0.54, 0.94) 0.75 (0.53, 0.91) 0.74 (0.53, 0.94) 0.74 (0.54, 0.88)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.026 (0, 0.063) 0.033 (0, 0.06) 0.032 (0, 0.072) 0.029 (0, 0.079) 0.03 (0, 0.07) 0.029 (0, 0.072) 0.029 (0, 0.07) 0.031 (0, 0.071)
Taxel_therapies count 1 1 1 1 1 1 1 1
time 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19)
n 2 (2, 2) 5 (5, 5) 5 (5, 5) 4 (4, 4) 3 (3, 3) 0 (0, 0) 5 (5, 5) 4 (4, 4)
post_p 0.52 (0.52, 0.52) 0.74 (0.74, 0.74) 0.84 (0.84, 0.84) 0.68 (0.68, 0.68) 0.62 (0.62, 0.62) NA (NA, NA) 0.76 (0.76, 0.76) 0.64 (0.64, 0.64)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.082 (0.082, 0.082) 0.087 (0.087, 0.087) 0.026 (0.026, 0.026) 0 (0, 0) 0.056 (0.056, 0.056) NA (NA, NA) 0.024 (0.024, 0.024) 0.033 (0.033, 0.033)
TEfus+ Hormone_therapies count 161 161 161 161 161 161 161 161
time 19 (11, 33) 19 (11, 33) 19 (11, 33) 19 (11, 33) 19 (11, 33) 19 (11, 33) 19 (11, 33) 19 (11, 33)
n 5 (2, 11) 13 (6, 32) 2 (0, 7) 2 (0, 7) 5 (1, 13) 4 (2, 12) 3 (0, 8) 3 (0, 6)
post_p 0.8 (0.56, 0.95) 0.88 (0.71, 0.99) 0.72 (0.55, 0.9) 0.73 (0.52, 0.88) 0.72 (0.52, 0.94) 0.77 (0.55, 0.94) 0.71 (0.54, 0.91) 0.69 (0.53, 0.87)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.031 (0, 0.071) 0.035 (0.008, 0.06) 0.03 (0, 0.073) 0.019 (0, 0.062) 0.035 (0, 0.074) 0.028 (0, 0.063) 0.019 (0, 0.078) 0.025 (0, 0.07)
Niraparib count 2 2 2 2 2 2 2 2
time 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15) 13 (11, 15)
n 4 (2, 5) 5 (3, 7) 8 (6, 10) 2 (1, 4) 2 (2, 3) 2 (1, 2) 2 (2, 3) 4 (4, 5)
post_p 0.56 (0.54, 0.57) 0.67 (0.54, 0.79) 0.84 (0.78, 0.9) 0.52 (0.52, 0.52) 0.54 (0.52, 0.57) 0.56 (0.52, 0.59) 0.54 (0.52, 0.57) 0.59 (0.55, 0.63)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.109 (0.062, 0.157) 0 (0, 0) 0.025 (0.005, 0.046) 0.041 (0.041, 0.041) 0.028 (0.006, 0.051) 0.035 (0.007, 0.062) 0.085 (0.082, 0.089) 0.054 (0.05, 0.058)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Taxel_therapies count 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96 96
time 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35) 28 (17, 35)
n 16 (6, 36) 6 (2, 12) 11 (5, 27) 10 (5, 28) 4 (1, 11) 4 (0, 12) 3 (0, 8) 2 (0, 6) 6 (3, 16) 5 (2, 10) 6 (2, 12) 5 (2, 10) 3 (1, 7) 3 (1, 7) 3 (0, 8) 2 (0, 6)
post_p 0.12 (0.02, 0.33) 0.25 (0.12, 0.45) 0.19 (0.07, 0.44) 0.19 (0.04, 0.42) 0.27 (0.15, 0.47) 0.28 (0.1, 0.45) 0.32 (0.18, 0.48) 0.3 (0.17, 0.46) 0.29 (0.09, 0.45) 0.28 (0.13, 0.44) 0.27 (0.13, 0.46) 0.27 (0.14, 0.45) 0.35 (0.17, 0.45) 0.32 (0.17, 0.46) 0.33 (0.14, 0.46) 0.34 (0.2, 0.47)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.122 (0.085, 0.213) 0.135 (0.083, 0.3) 0.122 (0.091, 0.198) 0.124 (0.089, 0.199) 0.156 (0.085, 0.456) 0.164 (0.09, 0.366) 0.148 (0.081, 0.358) 0.157 (0.095, 0.7) 0.137 (0.087, 0.275) 0.141 (0.082, 0.341) 0.13 (0.083, 0.267) 0.141 (0.088, 0.318) 0.157 (0.09, 0.453) 0.165 (0.084, 0.562) 0.155 (0.081, 0.487) 0.145 (0.083, 0.482)
Carboplatin count 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70 70
time 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35)
n 18 (8, 51) 4 (2, 13) 11 (5, 43) 8 (3, 22) 6 (2, 15) 6 (2, 15) 4 (1, 9) 3 (1, 8) 4 (2, 10) 3 (1, 8) 4 (1, 12) 4 (1, 10) 4 (1, 8) 4 (1, 8) 4 (1, 10) 4 (1, 10)
post_p 0.11 (0.02, 0.34) 0.29 (0.13, 0.45) 0.21 (0.06, 0.36) 0.24 (0.06, 0.4) 0.31 (0.12, 0.45) 0.31 (0.09, 0.46) 0.3 (0.18, 0.44) 0.31 (0.17, 0.42) 0.27 (0.11, 0.42) 0.32 (0.18, 0.45) 0.31 (0.11, 0.46) 0.28 (0.14, 0.43) 0.33 (0.17, 0.48) 0.3 (0.09, 0.47) 0.29 (0.18, 0.45) 0.32 (0.1, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.117 (0.086, 0.16) 0.149 (0.082, 0.51) 0.122 (0.09, 0.194) 0.126 (0.089, 0.374) 0.133 (0.087, 0.554) 0.135 (0.089, 0.311) 0.149 (0.093, 0.314) 0.178 (0.094, 0.456) 0.146 (0.102, 0.476) 0.14 (0.084, 0.452) 0.136 (0.084, 0.336) 0.168 (0.099, 0.608) 0.142 (0.097, 0.634) 0.144 (0.095, 0.492) 0.134 (0.084, 0.479) 0.144 (0.09, 0.5)
Niraparib count 77 77 77 77 77 77 77 77 77 77 77 77 77 77 77 77
time 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35)
n 20 (8, 57) 5 (1, 13) 11 (4, 40) 7 (4, 21) 6 (3, 12) 6 (3, 14) 4 (2, 9) 4 (1, 8) 5 (2, 12) 4 (1, 8) 4 (1, 12) 3 (1, 8) 4 (1, 8) 3 (1, 8) 4 (2, 8) 4 (2, 7)
post_p 0.1 (0.01, 0.29) 0.32 (0.14, 0.47) 0.17 (0.06, 0.4) 0.24 (0.1, 0.45) 0.31 (0.13, 0.47) 0.24 (0.12, 0.44) 0.31 (0.16, 0.47) 0.29 (0.13, 0.44) 0.29 (0.12, 0.47) 0.29 (0.16, 0.47) 0.32 (0.14, 0.44) 0.32 (0.11, 0.45) 0.31 (0.14, 0.46) 0.3 (0.17, 0.48) 0.32 (0.17, 0.46) 0.3 (0.16, 0.43)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.119 (0.094, 0.172) 0.123 (0.082, 0.604) 0.118 (0.086, 0.266) 0.117 (0.076, 0.255) 0.125 (0.087, 0.215) 0.143 (0.087, 0.311) 0.139 (0.09, 0.405) 0.148 (0.095, 0.453) 0.134 (0.081, 0.374) 0.16 (0.09, 0.658) 0.152 (0.089, 0.354) 0.145 (0.09, 0.527) 0.162 (0.098, 0.393) 0.179 (0.104, 0.438) 0.127 (0.085, 0.342) 0.145 (0.094, 0.455)
TP53- & AR- Hormone_therapies count 1 1 1 1
time 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6)
n 22 (22, 22) 3 (3, 3) 1 (1, 1) 0 (0, 0)
post_p 0.36 (0.36, 0.36) 0.16 (0.16, 0.16) 0.44 (0.44, 0.44) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.078 (0.078, 0.078) 0.284 (0.284, 0.284) 0 (0, 0) NA (NA, NA)
Taxel_therapies count 383 383 383 383
time 21 (13, 31) 21 (13, 31) 21 (13, 31) 21 (13, 31)
n 19 (10, 55) 6 (2, 15) 5 (2, 14) 5 (2, 14)
post_p 0.16 (0.02, 0.43) 0.33 (0.13, 0.47) 0.32 (0.15, 0.47) 0.36 (0.16, 0.47)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.117 (0.086, 0.18) 0.123 (0.08, 0.299) 0.145 (0.083, 0.429) 0.132 (0.078, 0.422)
Carboplatin count 396 396 396 396
time 20 (13, 31) 20 (13, 31) 20 (13, 31) 20 (13, 31)
n 20 (8, 66) 5 (2, 13) 7 (3, 15) 6 (2, 15)
post_p 0.18 (0.02, 0.44) 0.34 (0.16, 0.48) 0.34 (0.15, 0.48) 0.33 (0.11, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.114 (0.085, 0.182) 0.129 (0.075, 0.345) 0.121 (0.082, 0.33) 0.135 (0.081, 0.326)
Niraparib count 402 402 402 402
time 19 (13, 32) 19 (13, 32) 19 (13, 32) 19 (13, 32)
n 18 (8, 55) 5 (2, 13) 7 (3, 15) 6 (3, 13)
post_p 0.21 (0.03, 0.43) 0.35 (0.16, 0.48) 0.34 (0.13, 0.48) 0.32 (0.12, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.109 (0.083, 0.194) 0.124 (0.077, 0.464) 0.125 (0.085, 0.279) 0.129 (0.085, 0.314)
TP53+ Taxel_therapies count 263 263 263 263 263 263 263 263
time 24 (12, 33) 24 (12, 33) 24 (12, 33) 24 (12, 33) 24 (12, 33) 24 (12, 33) 24 (12, 33) 24 (12, 33)
n 12 (5, 33) 11 (6, 27) 3 (1, 8) 3 (1, 8) 5 (2, 14) 5 (2, 11) 3 (1, 8) 3 (0, 8)
post_p 0.19 (0.05, 0.43) 0.19 (0.04, 0.43) 0.35 (0.18, 0.48) 0.37 (0.21, 0.48) 0.3 (0.13, 0.46) 0.32 (0.14, 0.48) 0.35 (0.18, 0.48) 0.35 (0.18, 0.47)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.121 (0.083, 0.217) 0.124 (0.086, 0.216) 0.157 (0.077, 0.491) 0.143 (0.082, 0.526) 0.134 (0.084, 0.345) 0.135 (0.085, 0.296) 0.149 (0.071, 0.769) 0.155 (0.084, 0.602)
Carboplatin count 231 231 231 231 231 231 231 231
time 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34)
n 12 (5, 40) 9 (3, 27) 4 (1, 10) 4 (1, 10) 4 (1, 13) 4 (1, 13) 4 (1, 9) 4 (2, 10)
post_p 0.19 (0.03, 0.43) 0.23 (0.06, 0.45) 0.32 (0.16, 0.46) 0.33 (0.17, 0.47) 0.33 (0.16, 0.47) 0.33 (0.14, 0.47) 0.34 (0.17, 0.47) 0.33 (0.16, 0.48)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.122 (0.086, 0.23) 0.129 (0.087, 0.298) 0.141 (0.085, 0.366) 0.149 (0.08, 0.465) 0.136 (0.085, 0.43) 0.133 (0.082, 0.413) 0.139 (0.085, 0.415) 0.134 (0.078, 0.425)
Niraparib count 225 225 225 225 225 225 225 225
time 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34)
n 11 (5, 40) 8 (3, 24) 4 (2, 10) 4 (1, 9) 4 (1, 11) 4 (1, 11) 4 (1, 9) 4 (2, 9)
post_p 0.22 (0.05, 0.44) 0.23 (0.08, 0.46) 0.34 (0.16, 0.48) 0.32 (0.16, 0.47) 0.35 (0.17, 0.48) 0.34 (0.15, 0.47) 0.33 (0.15, 0.47) 0.33 (0.18, 0.47)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.115 (0.084, 0.239) 0.121 (0.086, 0.288) 0.137 (0.079, 0.383) 0.146 (0.081, 0.461) 0.138 (0.076, 0.357) 0.138 (0.079, 0.381) 0.143 (0.082, 0.454) 0.138 (0.085, 0.374)
DRD+ Taxel_therapies count 137 137 137 137 137 137 137 137
time 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34) 27 (20, 34)
n 5 (2, 13) 5 (2, 13) 3 (1, 9) 3 (1, 7) 3 (1, 8) 3 (1, 9) 4 (1, 9) 3 (1, 8)
post_p 0.3 (0.12, 0.47) 0.3 (0.12, 0.46) 0.33 (0.18, 0.48) 0.35 (0.19, 0.48) 0.36 (0.17, 0.46) 0.32 (0.18, 0.46) 0.34 (0.18, 0.46) 0.34 (0.19, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.151 (0.083, 0.4) 0.142 (0.081, 0.383) 0.149 (0.083, 0.48) 0.139 (0.087, 0.516) 0.15 (0.091, 0.395) 0.154 (0.087, 0.444) 0.141 (0.087, 0.649) 0.15 (0.081, 0.468)
Carboplatin count 199 199 199 199 199 199 199 199
time 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34) 25 (17, 34)
n 6 (2, 15) 6 (2, 15) 5 (2, 10) 4 (1, 9) 4 (1, 9) 4 (1, 10) 4 (1, 9) 4 (2, 10)
post_p 0.32 (0.12, 0.47) 0.27 (0.11, 0.47) 0.33 (0.16, 0.47) 0.34 (0.15, 0.46) 0.33 (0.15, 0.47) 0.35 (0.13, 0.47) 0.34 (0.16, 0.47) 0.32 (0.14, 0.48)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.122 (0.083, 0.327) 0.134 (0.088, 0.311) 0.141 (0.093, 0.351) 0.157 (0.085, 0.388) 0.14 (0.087, 0.452) 0.134 (0.084, 0.398) 0.138 (0.08, 0.431) 0.144 (0.087, 0.43)
Niraparib count 182 182 182 182 182 182 182 182
time 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34)
n 7 (3, 15) 6 (3, 14) 4 (2, 10) 4 (1, 10) 4 (1, 9) 4 (1, 10) 4 (1, 10) 4 (2, 9)
post_p 0.3 (0.11, 0.47) 0.31 (0.12, 0.45) 0.31 (0.16, 0.46) 0.3 (0.18, 0.48) 0.31 (0.15, 0.47) 0.32 (0.15, 0.48) 0.34 (0.16, 0.45) 0.34 (0.17, 0.47)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.129 (0.085, 0.244) 0.127 (0.09, 0.281) 0.146 (0.089, 0.404) 0.143 (0.083, 0.461) 0.158 (0.097, 0.394) 0.153 (0.088, 0.378) 0.145 (0.085, 0.454) 0.145 (0.085, 0.362)
TEfus+ Taxel_therapies count 224 224 224 224 224 224 224 224
time 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33) 23 (15, 33)
n 5 (2, 12) 11 (6, 29) 4 (1, 13) 3 (1, 7) 5 (2, 12) 5 (2, 11) 3 (1, 8) 3 (1, 7)
post_p 0.29 (0.12, 0.45) 0.2 (0.04, 0.45) 0.33 (0.13, 0.46) 0.34 (0.19, 0.46) 0.3 (0.13, 0.46) 0.32 (0.13, 0.47) 0.35 (0.17, 0.46) 0.35 (0.17, 0.48)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.138 (0.087, 0.341) 0.123 (0.089, 0.201) 0.144 (0.081, 0.446) 0.148 (0.085, 0.577) 0.138 (0.086, 0.354) 0.132 (0.086, 0.3) 0.154 (0.082, 0.487) 0.155 (0.082, 0.544)
Carboplatin count 203 203 203 203 203 203 203 203
time 26 (15, 33) 26 (15, 33) 26 (15, 33) 26 (15, 33) 26 (15, 33) 26 (15, 33) 26 (15, 33) 26 (15, 33)
n 5 (2, 13) 9 (3, 25) 6 (2, 15) 4 (1, 9) 4 (1, 11) 4 (1, 13) 4 (2, 10) 4 (2, 10)
post_p 0.32 (0.14, 0.47) 0.24 (0.07, 0.43) 0.3 (0.09, 0.46) 0.31 (0.14, 0.45) 0.31 (0.17, 0.47) 0.33 (0.15, 0.47) 0.32 (0.13, 0.47) 0.33 (0.14, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.132 (0.078, 0.358) 0.121 (0.088, 0.291) 0.131 (0.086, 0.307) 0.152 (0.082, 0.496) 0.138 (0.08, 0.423) 0.137 (0.087, 0.397) 0.136 (0.087, 0.443) 0.135 (0.085, 0.433)
Niraparib count 231 231 231 231 231 231 231 231
time 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34) 26 (16, 34)
n 4 (2, 13) 9 (3, 25) 7 (3, 15) 4 (1, 9) 4 (1, 9) 4 (1, 10) 4 (1, 10) 4 (2, 10)
post_p 0.33 (0.12, 0.47) 0.23 (0.09, 0.45) 0.3 (0.12, 0.46) 0.33 (0.14, 0.47) 0.33 (0.15, 0.47) 0.34 (0.15, 0.46) 0.31 (0.15, 0.47) 0.32 (0.16, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.133 (0.084, 0.419) 0.121 (0.085, 0.29) 0.134 (0.087, 0.298) 0.145 (0.086, 0.45) 0.147 (0.083, 0.594) 0.14 (0.084, 0.386) 0.14 (0.081, 0.408) 0.139 (0.087, 0.339)