Hormone_therapies more effective in all the biomarker signatures
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| —+ | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –+- | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –++ | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+– | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -++- | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+++ | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +— | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +–+ | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-+- | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-++ | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++– | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +++- | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++++ | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TP53- & AR- | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| DRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.039, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 25, median = 18 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.85, hr = 0.33 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
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The overall error was 0.448.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.442 0.006 0.002 0.008
The overall power was 0.544.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.544 0.000 0.000 0.000
| signature | var | Control | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 272 | 0 | 0 | 0 |
| futility | 0 | 0 | 96 | 70 | 77 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 434 (366, 478) | 132 (34, 264) | 148 (93, 236) | 154 (97, 249) | 156 (94, 231) | |
| n_unique | 408 (343, 449) | 125 (32, 249) | 137 (86, 225) | 144 (90, 236) | 145 (88, 215) | |
| time_trial | 36 (36, 36) | 32 (5, 36) | 36 (29, 36) | 36 (33, 36) | 36 (32, 36) | |
| time_stop | NA (NA, NA) | 10 (4, 30) | 28 (17, 35) | 30 (20, 35) | 30 (20, 35) | |
| post_p | NA (NA, NA) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | |
| rate | 0.073 (0.067, 0.079) | 0.038 (0.032, 0.045) | 0.114 (0.102, 0.129) | 0.114 (0.101, 0.13) | 0.113 (0.101, 0.127) | |
| TP53- & AR- | graduation | 0 | 366 | 2 | 1 | 1 |
| futility | 0 | 1 | 383 | 396 | 402 | |
| max_n | 0 | 18 | 16 | 24 | 10 | |
| n | 173 (107, 204) | 32 (19, 132) | 39 (25, 120) | 44 (25, 124) | 42 (25, 115) | |
| n_unique | 162 (97, 192) | 30 (18, 125) | 35 (23, 114) | 42 (23, 121) | 39 (24, 109) | |
| time_trial | 36 (36, 36) | 12 (7, 36) | 23 (14, 36) | 23 (13, 36) | 22 (13, 36) | |
| time_stop | NA (NA, NA) | 9 (6, 25) | 21 (13, 31) | 20 (13, 31) | 19 (13, 32) | |
| post_p | NA (NA, NA) | 1 (0.95, 1) | 0.01 (0, 0.09) | 0.01 (0, 0.1) | 0.01 (0, 0.11) | |
| rate | 0.072 (0.063, 0.083) | 0.039 (0.03, 0.05) | 0.117 (0.098, 0.149) | 0.116 (0.096, 0.147) | 0.115 (0.095, 0.146) | |
| TP53+ | graduation | 0 | 235 | 0 | 0 | 1 |
| futility | 0 | 0 | 263 | 231 | 225 | |
| max_n | 0 | 72 | 12 | 27 | 19 | |
| n | 202 (177, 225) | 48 (13, 152) | 67 (32, 129) | 70 (34, 135) | 70 (33, 134) | |
| n_unique | 189 (165, 210) | 45 (12, 142) | 62 (31, 120) | 64 (31, 130) | 65 (31, 124) | |
| time_trial | 36 (36, 36) | 36 (10, 36) | 35 (15, 36) | 36 (19, 36) | 36 (17, 36) | |
| time_stop | NA (NA, NA) | 13 (9, 32) | 24 (12, 33) | 26 (14, 34) | 24 (14, 34) | |
| post_p | NA (NA, NA) | 1 (0.97, 1) | 0 (0, 0.07) | 0 (0, 0.07) | 0.01 (0, 0.07) | |
| rate | 0.073 (0.064, 0.082) | 0.038 (0.029, 0.047) | 0.115 (0.096, 0.141) | 0.115 (0.097, 0.14) | 0.113 (0.097, 0.137) | |
| DRD+ | graduation | 0 | 100 | 1 | 0 | 0 |
| futility | 0 | 0 | 137 | 199 | 182 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 113 (91, 134) | 26 (2, 56) | 42 (25, 71) | 53 (31, 81) | 53 (32, 79) | |
| n_unique | 105 (86, 125) | 24 (1, 53) | 39 (22, 67) | 48 (29, 75) | 50 (30, 74) | |
| time_trial | 36 (36, 36) | 36 (24, 36) | 36 (26, 36) | 36 (21, 36) | 36 (21, 36) | |
| time_stop | NA (NA, NA) | 24 (17, 33) | 27 (20, 34) | 25 (17, 34) | 26 (16, 34) | |
| post_p | NA (NA, NA) | 0.99 (0.77, 1) | 0.03 (0, 0.19) | 0.02 (0, 0.14) | 0.01 (0, 0.14) | |
| rate | 0.073 (0.062, 0.085) | 0.037 (0.024, 0.054) | 0.115 (0.093, 0.151) | 0.115 (0.097, 0.142) | 0.116 (0.097, 0.142) | |
| TEfus+ | graduation | 0 | 161 | 0 | 0 | 2 |
| futility | 0 | 0 | 224 | 203 | 231 | |
| max_n | 0 | 0 | 0 | 0 | 1 | |
| n | 154 (131, 179) | 38 (8, 95) | 59 (32, 104) | 63 (33, 104) | 60 (30, 98) | |
| n_unique | 144 (121, 167) | 35 (7, 89) | 55 (29, 97) | 58 (31, 95) | 56 (29, 91) | |
| time_trial | 36 (36, 36) | 36 (15, 36) | 36 (17, 36) | 36 (21, 36) | 36 (20, 36) | |
| time_stop | NA (NA, NA) | 19 (11, 33) | 23 (15, 33) | 26 (15, 33) | 26 (16, 34) | |
| post_p | NA (NA, NA) | 1 (0.92, 1) | 0.01 (0, 0.1) | 0.01 (0, 0.11) | 0.01 (0, 0.09) | |
| rate | 0.072 (0.064, 0.082) | 0.039 (0.028, 0.049) | 0.114 (0.095, 0.141) | 0.114 (0.096, 0.142) | 0.115 (0.095, 0.142) |
| subtype | var | Control | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 465 | 401 | 404 | 407 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 18 | 16 | 24 | 10 | |
| n | 111 (69, 134) | 25 (15, 100) | 21 (9, 77) | 23 (8, 80) | 20 (8, 74) | |
| n_unique | 104 (62, 127) | 24 (15, 95) | 19 (8, 74) | 21 (8, 77) | 19 (7, 73) | |
| post_p | NA (NA, NA) | 1 (0.88, 1) | 0.06 (0, 0.23) | 0.06 (0, 0.27) | 0.07 (0.01, 0.3) | |
| rate | 0.072 (0.061, 0.085) | 0.039 (0.029, 0.054) | 0.119 (0.094, 0.181) | 0.118 (0.091, 0.166) | 0.117 (0.089, 0.174) | |
| —+ | graduation | 0 | 472 | 423 | 418 | 432 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 18 | 16 | 23 | 11 | |
| n | 19 (10, 28) | 4 (1, 13) | 7 (2, 18) | 6 (2, 18) | 6 (2, 15) | |
| n_unique | 17 (9, 26) | 4 (1, 11) | 6 (2, 17) | 5 (2, 17) | 5 (2, 15) | |
| post_p | NA (NA, NA) | 0.85 (0.51, 0.98) | 0.27 (0.1, 0.53) | 0.29 (0.12, 0.61) | 0.29 (0.12, 0.57) | |
| rate | 0.073 (0.049, 0.105) | 0.037 (0.013, 0.086) | 0.121 (0.082, 0.272) | 0.123 (0.072, 0.319) | 0.122 (0.073, 0.371) | |
| –+- | graduation | 0 | 371 | 269 | 234 | 228 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 70 | 12 | 27 | 19 | |
| n | 71 (57, 83) | 22 (7, 68) | 14 (5, 52) | 16 (5, 53) | 15 (5, 52) | |
| n_unique | 67 (54, 78) | 21 (7, 64) | 13 (5, 49) | 14 (5, 50) | 14 (5, 50) | |
| post_p | NA (NA, NA) | 0.99 (0.83, 1) | 0.12 (0.03, 0.37) | 0.12 (0.02, 0.36) | 0.14 (0.02, 0.38) | |
| rate | 0.074 (0.06, 0.09) | 0.038 (0.026, 0.053) | 0.12 (0.087, 0.219) | 0.121 (0.089, 0.223) | 0.118 (0.086, 0.21) | |
| –++ | graduation | 0 | 405 | 338 | 308 | 314 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 67 | 12 | 26 | 18 | |
| n | 46 (34, 57) | 10 (2, 37) | 14 (6, 37) | 13 (4, 36) | 11 (4, 33) | |
| n_unique | 43 (31, 53) | 10 (2, 35) | 12 (6, 35) | 12 (3, 35) | 10 (3, 31) | |
| post_p | NA (NA, NA) | 0.94 (0.57, 1) | 0.14 (0.03, 0.45) | 0.16 (0.03, 0.44) | 0.18 (0.04, 0.5) | |
| rate | 0.073 (0.056, 0.093) | 0.04 (0.022, 0.07) | 0.118 (0.086, 0.2) | 0.121 (0.086, 0.242) | 0.12 (0.081, 0.258) | |
| -+– | graduation | 0 | 472 | 415 | 418 | 415 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 18 | 16 | 24 | 10 | |
| n | 19 (10, 26) | 2 (0, 10) | 6 (2, 17) | 7 (3, 20) | 8 (3, 18) | |
| n_unique | 17 (9, 25) | 1 (0, 9) | 5 (1, 15) | 7 (2, 19) | 7 (3, 17) | |
| post_p | NA (NA, NA) | 0.8 (0.49, 0.97) | 0.27 (0.1, 0.57) | 0.28 (0.1, 0.58) | 0.27 (0.09, 0.55) | |
| rate | 0.076 (0.051, 0.108) | 0.037 (0, 0.097) | 0.137 (0.077, 0.405) | 0.126 (0.082, 0.32) | 0.125 (0.082, 0.249) | |
| -+-+ | graduation | 0 | 478 | 435 | 429 | 438 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 18 | 16 | 23 | 11 | |
| n | 18 (11, 26) | 2 (0, 7) | 6 (2, 17) | 7 (2, 18) | 7 (3, 17) | |
| n_unique | 17 (10, 25) | 1 (0, 7) | 5 (1, 16) | 6 (2, 17) | 7 (2, 16) | |
| post_p | NA (NA, NA) | 0.78 (0.42, 0.95) | 0.3 (0.11, 0.6) | 0.26 (0.08, 0.57) | 0.26 (0.1, 0.54) | |
| rate | 0.072 (0.049, 0.107) | 0.041 (0, 0.135) | 0.127 (0.075, 0.343) | 0.128 (0.084, 0.303) | 0.125 (0.082, 0.289) | |
| -++- | graduation | 0 | 392 | 296 | 294 | 276 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 70 | 12 | 27 | 18 | |
| n | 12 (7, 18) | 2 (0, 9) | 4 (1, 11) | 5 (2, 12) | 5 (2, 12) | |
| n_unique | 12 (7, 17) | 2 (0, 8) | 4 (1, 10) | 5 (2, 11) | 5 (2, 11) | |
| post_p | NA (NA, NA) | 0.77 (0.41, 0.96) | 0.34 (0.16, 0.62) | 0.32 (0.15, 0.63) | 0.32 (0.14, 0.62) | |
| rate | 0.074 (0.047, 0.121) | 0.043 (0, 0.134) | 0.131 (0.069, 0.402) | 0.126 (0.073, 0.33) | 0.129 (0.071, 0.359) | |
| -+++ | graduation | 0 | 415 | 352 | 343 | 346 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 67 | 12 | 26 | 17 | |
| n | 12 (8, 17) | 2 (0, 9) | 4 (1, 11) | 5 (1, 12) | 5 (2, 12) | |
| n_unique | 12 (7, 16) | 2 (0, 8) | 3 (1, 10) | 5 (1, 12) | 5 (2, 11) | |
| post_p | NA (NA, NA) | 0.77 (0.4, 0.94) | 0.34 (0.17, 0.6) | 0.32 (0.13, 0.61) | 0.3 (0.14, 0.58) | |
| rate | 0.072 (0.046, 0.112) | 0.043 (0.004, 0.142) | 0.134 (0.067, 0.468) | 0.135 (0.071, 0.361) | 0.134 (0.073, 0.409) | |
| +— | graduation | 0 | 272 | 96 | 70 | 77 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 22 (15, 28) | 9 (1, 24) | 8 (3, 19) | 6 (2, 17) | 6 (2, 16) | |
| n_unique | 21 (14, 27) | 8 (1, 22) | 8 (3, 18) | 6 (2, 16) | 6 (2, 15) | |
| post_p | NA (NA, NA) | 0.86 (0.47, 0.99) | 0.23 (0.09, 0.54) | 0.27 (0.1, 0.57) | 0.28 (0.11, 0.59) | |
| rate | 0.074 (0.05, 0.105) | 0.041 (0.018, 0.085) | 0.124 (0.08, 0.252) | 0.131 (0.074, 0.355) | 0.123 (0.071, 0.285) | |
| +–+ | graduation | 0 | 342 | 230 | 210 | 234 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 1 | |
| n | 17 (11, 23) | 5 (1, 17) | 7 (3, 15) | 6 (2, 14) | 5 (2, 15) | |
| n_unique | 16 (10, 22) | 4 (0, 15) | 6 (2, 14) | 5 (2, 13) | 4 (2, 14) | |
| post_p | NA (NA, NA) | 0.81 (0.46, 0.98) | 0.27 (0.1, 0.57) | 0.31 (0.13, 0.62) | 0.3 (0.13, 0.58) | |
| rate | 0.073 (0.049, 0.11) | 0.042 (0.017, 0.095) | 0.126 (0.075, 0.288) | 0.124 (0.067, 0.332) | 0.128 (0.075, 0.411) | |
| +-+- | graduation | 0 | 371 | 269 | 234 | 228 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 70 | 12 | 27 | 19 | |
| n | 17 (11, 24) | 3 (0, 14) | 6 (2, 15) | 6 (2, 15) | 6 (2, 16) | |
| n_unique | 16 (11, 22) | 3 (0, 13) | 6 (2, 15) | 5 (2, 15) | 6 (1, 15) | |
| post_p | NA (NA, NA) | 0.8 (0.45, 0.97) | 0.25 (0.1, 0.57) | 0.31 (0.13, 0.57) | 0.3 (0.12, 0.61) | |
| rate | 0.073 (0.046, 0.108) | 0.04 (0.012, 0.098) | 0.134 (0.082, 0.351) | 0.122 (0.074, 0.351) | 0.126 (0.069, 0.354) | |
| +-++ | graduation | 0 | 405 | 338 | 308 | 314 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 67 | 12 | 26 | 18 | |
| n | 17 (11, 23) | 3 (0, 14) | 6 (2, 15) | 6 (2, 14) | 6 (2, 15) | |
| n_unique | 15 (10, 22) | 3 (0, 14) | 6 (2, 15) | 5 (1, 13) | 5 (1, 14) | |
| post_p | NA (NA, NA) | 0.82 (0.47, 0.97) | 0.28 (0.1, 0.57) | 0.29 (0.13, 0.59) | 0.31 (0.12, 0.61) | |
| rate | 0.073 (0.05, 0.109) | 0.038 (0.014, 0.097) | 0.125 (0.078, 0.288) | 0.127 (0.072, 0.298) | 0.126 (0.072, 0.339) | |
| ++– | graduation | 0 | 319 | 169 | 206 | 182 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 13 (8, 18) | 3 (0, 12) | 4 (1, 11) | 5 (2, 12) | 5 (2, 12) | |
| n_unique | 12 (7, 17) | 3 (0, 12) | 4 (1, 10) | 4 (2, 11) | 5 (2, 11) | |
| post_p | NA (NA, NA) | 0.83 (0.46, 0.98) | 0.35 (0.15, 0.64) | 0.3 (0.13, 0.6) | 0.3 (0.13, 0.62) | |
| rate | 0.078 (0.045, 0.128) | 0.036 (0.011, 0.113) | 0.131 (0.067, 0.409) | 0.139 (0.078, 0.371) | 0.135 (0.075, 0.371) | |
| ++-+ | graduation | 0 | 370 | 276 | 286 | 298 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 1 | |
| n | 12 (8, 18) | 2 (0, 10) | 4 (1, 11) | 5 (2, 13) | 5 (2, 12) | |
| n_unique | 12 (7, 17) | 2 (0, 9) | 4 (1, 10) | 5 (2, 12) | 5 (2, 11) | |
| post_p | NA (NA, NA) | 0.8 (0.44, 0.96) | 0.34 (0.16, 0.63) | 0.29 (0.11, 0.61) | 0.3 (0.13, 0.61) | |
| rate | 0.074 (0.044, 0.12) | 0.04 (0.009, 0.108) | 0.133 (0.072, 0.401) | 0.128 (0.076, 0.367) | 0.134 (0.076, 0.352) | |
| +++- | graduation | 0 | 392 | 296 | 294 | 276 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 70 | 12 | 27 | 18 | |
| n | 12 (7, 18) | 2 (0, 10) | 4 (1, 10) | 5 (2, 12) | 5 (2, 13) | |
| n_unique | 12 (6, 17) | 2 (0, 9) | 3 (1, 10) | 5 (2, 11) | 4 (2, 11) | |
| post_p | NA (NA, NA) | 0.77 (0.42, 0.96) | 0.33 (0.16, 0.62) | 0.33 (0.14, 0.61) | 0.3 (0.14, 0.61) | |
| rate | 0.072 (0.044, 0.12) | 0.039 (0.01, 0.112) | 0.133 (0.069, 0.512) | 0.129 (0.073, 0.32) | 0.133 (0.073, 0.41) | |
| ++++ | graduation | 0 | 415 | 352 | 343 | 346 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 67 | 12 | 26 | 17 | |
| n | 12 (7, 18) | 2 (0, 8) | 4 (1, 11) | 5 (2, 12) | 5 (2, 12) | |
| n_unique | 12 (7, 17) | 2 (0, 8) | 3 (1, 10) | 5 (1, 12) | 5 (2, 12) | |
| post_p | NA (NA, NA) | 0.78 (0.41, 0.95) | 0.34 (0.15, 0.63) | 0.33 (0.13, 0.62) | 0.32 (0.14, 0.62) | |
| rate | 0.072 (0.045, 0.121) | 0.042 (0, 0.122) | 0.133 (0.068, 0.458) | 0.127 (0.075, 0.378) | 0.128 (0.073, 0.318) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 272 | |||
| time_stop | 10 (4, 30) | ||||
| n_trt | 70 (30, 204) | ||||
| n_control | 110 (46, 360) | ||||
| post_p | 1 (0.93, 1) | ||||
| order | 2 (1, 3) | ||||
| TP53- & AR- | count | 366 | 2 | 1 | 1 |
| time_stop | 9 (6, 26) | 10 (9, 12) | 12 (12, 12) | 13 (13, 13) | |
| n_trt | 33 (26, 106) | 29 (29, 29) | 30 (30, 30) | 26 (26, 26) | |
| n_control | 41 (27, 118) | 35 (34, 36) | 57 (57, 57) | 59 (59, 59) | |
| post_p | 0.96 (0.88, 1) | 0.94 (0.9, 0.97) | 0.9 (0.9, 0.9) | 0.88 (0.88, 0.88) | |
| order | 1 (1, 2) | 2 (2, 2) | 3 (3, 3) | 2 (2, 2) | |
| TP53+ | count | 235 | 1 | ||
| time_stop | 13 (9, 32) | 9 (9, 9) | |||
| n_trt | 43 (27, 126) | 25 (25, 25) | |||
| n_control | 64 (36, 174) | 37 (37, 37) | |||
| post_p | 1 (0.94, 1) | 0.96 (0.96, 0.96) | |||
| order | 2 (1, 4) | 1 (1, 1) | |||
| DRD+ | count | 100 | 1 | ||
| time_stop | 24 (17, 33) | 19 (19, 19) | |||
| n_trt | 30 (25, 51) | 28 (28, 28) | |||
| n_control | 74 (47, 110) | 48 (48, 48) | |||
| post_p | 0.99 (0.95, 1) | 0.98 (0.98, 0.98) | |||
| order | 3 (1.9, 5) | 3 (3, 3) | |||
| TEfus+ | count | 161 | 2 | ||
| time_stop | 19 (11, 33) | 13 (11, 15) | |||
| n_trt | 38 (26, 83) | 30 (27, 33) | |||
| n_control | 74 (42, 144) | 48 (38, 58) | |||
| post_p | 1 (0.96, 1) | 0.9 (0.87, 0.93) | |||
| order | 3 (2, 5) | 1.5 (1.1, 1.9) |
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 96 | 70 | 77 | |
| time_stop | 28 (17, 35) | 30 (20, 35) | 30 (20, 35) | ||
| n_trt | 102 (70, 169) | 110 (74, 175) | 111 (76, 186) | ||
| n_control | 334 (190, 418) | 348 (238, 435) | 346 (247, 436) | ||
| post_p | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| order | 6 (2, 9) | 6 (3, 10) | 6 (3, 10) | ||
| TP53- & AR- | count | 1 | 383 | 396 | 402 |
| time_stop | 6 (6, 6) | 21 (13, 31) | 20 (13, 31) | 19 (13, 32) | |
| n_trt | 26 (26, 26) | 35 (25, 92) | 37 (25, 102) | 36 (25, 85) | |
| n_control | 26 (26, 26) | 104 (60, 166) | 101 (58, 162) | 97 (57, 165) | |
| post_p | 0.27 (0.27, 0.27) | 0.04 (0, 0.18) | 0.05 (0, 0.21) | 0.06 (0, 0.2) | |
| order | 1 (1, 1) | 3 (1, 6) | 3 (1, 6) | 3 (1, 6) | |
| TP53+ | count | 263 | 231 | 225 | |
| time_stop | 24 (12, 33) | 26 (14, 34) | 24 (14, 34) | ||
| n_trt | 49 (27, 97) | 54 (27, 105) | 48 (28, 100) | ||
| n_control | 122 (53, 191) | 140 (70, 191) | 129 (64, 193) | ||
| post_p | 0.01 (0, 0.07) | 0.01 (0, 0.07) | 0.01 (0, 0.06) | ||
| order | 4 (1, 8) | 5 (1, 8) | 3 (1, 8) | ||
| DRD+ | count | 137 | 199 | 182 | |
| time_stop | 27 (20, 34) | 25 (17, 34) | 26 (16, 34) | ||
| n_trt | 34 (26, 56) | 42 (28, 65) | 40 (27, 64) | ||
| n_control | 86 (59, 114) | 81 (50, 113) | 80 (47, 111) | ||
| post_p | 0.01 (0, 0.06) | 0.01 (0, 0.05) | 0.01 (0, 0.06) | ||
| order | 6 (3, 9) | 5 (2, 8.2) | 5 (2, 8) | ||
| TEfus+ | count | 224 | 203 | 231 | |
| time_stop | 23 (15, 33) | 26 (15, 33) | 26 (16, 34) | ||
| n_trt | 45 (27, 81) | 47 (29, 80) | 45 (27, 78) | ||
| n_control | 102 (55, 149) | 111 (56, 150) | 113 (63, 153) | ||
| post_p | 0.01 (0, 0.07) | 0.01 (0, 0.06) | 0.01 (0, 0.05) | ||
| order | 4 (1, 9) | 5 (2, 9) | 5 (2, 8) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 272 | 272 | 272 | 272 | 272 | 272 | 272 | 272 | 272 | 272 | 272 | 272 | 272 | 272 | 272 | 272 |
| time | 10 (4, 30) | 10 (4, 30) | 10 (4, 30) | 10 (4, 30) | 10 (4, 30) | 10 (4, 30) | 10 (4, 30) | 10 (4, 30) | 10 (4, 30) | 10 (4, 30) | 10 (4, 30) | 10 (4, 30) | 10 (4, 30) | 10 (4, 30) | 10 (4, 30) | 10 (4, 30) | ||
| n | 22 (13, 55) | 3 (1, 8) | 13 (5, 43) | 6 (1, 24) | 1 (0, 5) | 1 (0, 5) | 1 (0, 6) | 1 (0, 5) | 4 (0, 14) | 2 (0, 9) | 2 (0, 8) | 2 (0, 8) | 1 (0, 7) | 1 (0, 6) | 1 (0, 6) | 1 (0, 5) | ||
| post_p | 0.91 (0.64, 1) | 0.7 (0.53, 0.9) | 0.84 (0.6, 1) | 0.72 (0.53, 0.98) | 0.62 (0.52, 0.9) | 0.64 (0.51, 0.88) | 0.62 (0.52, 0.91) | 0.68 (0.52, 0.89) | 0.66 (0.52, 0.91) | 0.62 (0.52, 0.93) | 0.65 (0.52, 0.92) | 0.64 (0.53, 0.91) | 0.62 (0.52, 0.93) | 0.63 (0.52, 0.91) | 0.66 (0.52, 0.88) | 0.64 (0.53, 0.88) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.036 (0, 0.057) | 0.01 (0, 0.073) | 0.033 (0, 0.058) | 0.024 (0, 0.066) | 0 (0, 0.07) | 0 (0, 0.076) | 0 (0, 0.071) | 0 (0, 0.072) | 0.013 (0, 0.074) | 0 (0, 0.072) | 0 (0, 0.078) | 0 (0, 0.064) | 0 (0, 0.075) | 0 (0, 0.079) | 0.014 (0, 0.078) | 0 (0, 0.07) | ||
| TP53- & AR- | count | 366 | 366 | 366 | 366 | |||||||||||||
| time | 9 (6, 26) | 9 (6, 26) | 9 (6, 26) | 9 (6, 26) | ||||||||||||||
| n | 26 (20, 74) | 4 (2, 11) | 2 (0, 9) | 2 (0, 6) | ||||||||||||||
| post_p | 0.9 (0.75, 1) | 0.71 (0.54, 0.87) | 0.61 (0.52, 0.85) | 0.61 (0.51, 0.83) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.035 (0.016, 0.055) | 0.024 (0, 0.074) | 0 (0, 0.062) | 0 (0, 0.072) | ||||||||||||||
| Taxel_therapies | count | 2 | 2 | 2 | 2 | |||||||||||||
| time | 10 (9, 12) | 10 (9, 12) | 10 (9, 12) | 10 (9, 12) | ||||||||||||||
| n | 20 (18, 21) | 4 (4, 5) | 2 (2, 2) | 3 (2, 4) | ||||||||||||||
| post_p | 0.79 (0.72, 0.86) | 0.65 (0.61, 0.69) | 0.6 (0.52, 0.68) | 0.74 (0.74, 0.74) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.038 (0.024, 0.052) | 0.067 (0.055, 0.08) | 0.044 (0.009, 0.079) | 0 (0, 0) | ||||||||||||||
| Carboplatin | count | 1 | 1 | 1 | 1 | |||||||||||||
| time | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | ||||||||||||||
| n | 14 (14, 14) | 3 (3, 3) | 3 (3, 3) | 10 (10, 10) | ||||||||||||||
| post_p | 0.71 (0.71, 0.71) | 0.62 (0.62, 0.62) | 0.56 (0.56, 0.56) | 0.8 (0.8, 0.8) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.029 (0.029, 0.029) | 0 (0, 0) | 0.063 (0.063, 0.063) | 0.032 (0.032, 0.032) | ||||||||||||||
| Niraparib | count | 1 | 1 | 1 | 1 | |||||||||||||
| time | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | 13 (13, 13) | ||||||||||||||
| n | 10 (10, 10) | 3 (3, 3) | 4 (4, 4) | 9 (9, 9) | ||||||||||||||
| post_p | 0.72 (0.72, 0.72) | 0.56 (0.56, 0.56) | 0.56 (0.56, 0.56) | 0.84 (0.84, 0.84) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.041 (0.041, 0.041) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0.036 (0.036, 0.036) | ||||||||||||||
| TP53+ | Hormone_therapies | count | 235 | 235 | 235 | 235 | 235 | 235 | 235 | 235 | ||||||||
| time | 13 (9, 32) | 13 (9, 32) | 13 (9, 32) | 13 (9, 32) | 13 (9, 32) | 13 (9, 32) | 13 (9, 32) | 13 (9, 32) | ||||||||||
| n | 20 (12, 53) | 10 (4, 28) | 2 (0, 6) | 2 (0, 6) | 3 (0, 10) | 3 (1, 11) | 2 (0, 6) | 2 (0, 6) | ||||||||||
| post_p | 0.91 (0.75, 1) | 0.83 (0.61, 0.99) | 0.62 (0.52, 0.87) | 0.66 (0.52, 0.87) | 0.7 (0.52, 0.93) | 0.72 (0.53, 0.91) | 0.65 (0.52, 0.9) | 0.63 (0.53, 0.87) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.035 (0.013, 0.056) | 0.033 (0, 0.063) | 0 (0, 0.075) | 0 (0, 0.071) | 0.02 (0, 0.078) | 0.018 (0, 0.064) | 0 (0, 0.065) | 0 (0, 0.078) | ||||||||||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | 9 (9, 9) | ||||||||||
| n | 5 (5, 5) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 4 (4, 4) | 2 (2, 2) | 0 (0, 0) | 2 (2, 2) | ||||||||||
| post_p | 0.74 (0.74, 0.74) | 0.64 (0.64, 0.64) | 0.65 (0.65, 0.65) | 0.74 (0.74, 0.74) | 0.61 (0.61, 0.61) | 0.57 (0.57, 0.57) | NA (NA, NA) | 0.63 (0.63, 0.63) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0 (0, 0) | 0 (0, 0) | 0.053 (0.053, 0.053) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | ||||||||||
| DRD+ | Hormone_therapies | count | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | ||||||||
| time | 24 (17, 33) | 24 (17, 33) | 24 (17, 33) | 24 (17, 33) | 24 (17, 33) | 24 (17, 33) | 24 (17, 33) | 24 (17, 33) | ||||||||||
| n | 3 (1, 11) | 3 (0, 12) | 4 (1, 9) | 3 (0, 8) | 4 (1, 10) | 4 (2, 9) | 3 (1, 10) | 3 (0, 8) | ||||||||||
| post_p | 0.76 (0.62, 0.94) | 0.78 (0.59, 0.92) | 0.73 (0.55, 0.94) | 0.71 (0.53, 0.9) | 0.72 (0.54, 0.94) | 0.75 (0.53, 0.91) | 0.74 (0.53, 0.94) | 0.74 (0.54, 0.88) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.026 (0, 0.063) | 0.033 (0, 0.06) | 0.032 (0, 0.072) | 0.029 (0, 0.079) | 0.03 (0, 0.07) | 0.029 (0, 0.072) | 0.029 (0, 0.07) | 0.031 (0, 0.071) | ||||||||||
| Taxel_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 19 (19, 19) | 19 (19, 19) | 19 (19, 19) | 19 (19, 19) | 19 (19, 19) | 19 (19, 19) | 19 (19, 19) | 19 (19, 19) | ||||||||||
| n | 2 (2, 2) | 5 (5, 5) | 5 (5, 5) | 4 (4, 4) | 3 (3, 3) | 0 (0, 0) | 5 (5, 5) | 4 (4, 4) | ||||||||||
| post_p | 0.52 (0.52, 0.52) | 0.74 (0.74, 0.74) | 0.84 (0.84, 0.84) | 0.68 (0.68, 0.68) | 0.62 (0.62, 0.62) | NA (NA, NA) | 0.76 (0.76, 0.76) | 0.64 (0.64, 0.64) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.082 (0.082, 0.082) | 0.087 (0.087, 0.087) | 0.026 (0.026, 0.026) | 0 (0, 0) | 0.056 (0.056, 0.056) | NA (NA, NA) | 0.024 (0.024, 0.024) | 0.033 (0.033, 0.033) | ||||||||||
| TEfus+ | Hormone_therapies | count | 161 | 161 | 161 | 161 | 161 | 161 | 161 | 161 | ||||||||
| time | 19 (11, 33) | 19 (11, 33) | 19 (11, 33) | 19 (11, 33) | 19 (11, 33) | 19 (11, 33) | 19 (11, 33) | 19 (11, 33) | ||||||||||
| n | 5 (2, 11) | 13 (6, 32) | 2 (0, 7) | 2 (0, 7) | 5 (1, 13) | 4 (2, 12) | 3 (0, 8) | 3 (0, 6) | ||||||||||
| post_p | 0.8 (0.56, 0.95) | 0.88 (0.71, 0.99) | 0.72 (0.55, 0.9) | 0.73 (0.52, 0.88) | 0.72 (0.52, 0.94) | 0.77 (0.55, 0.94) | 0.71 (0.54, 0.91) | 0.69 (0.53, 0.87) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.031 (0, 0.071) | 0.035 (0.008, 0.06) | 0.03 (0, 0.073) | 0.019 (0, 0.062) | 0.035 (0, 0.074) | 0.028 (0, 0.063) | 0.019 (0, 0.078) | 0.025 (0, 0.07) | ||||||||||
| Niraparib | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 13 (11, 15) | 13 (11, 15) | 13 (11, 15) | 13 (11, 15) | 13 (11, 15) | 13 (11, 15) | 13 (11, 15) | 13 (11, 15) | ||||||||||
| n | 4 (2, 5) | 5 (3, 7) | 8 (6, 10) | 2 (1, 4) | 2 (2, 3) | 2 (1, 2) | 2 (2, 3) | 4 (4, 5) | ||||||||||
| post_p | 0.56 (0.54, 0.57) | 0.67 (0.54, 0.79) | 0.84 (0.78, 0.9) | 0.52 (0.52, 0.52) | 0.54 (0.52, 0.57) | 0.56 (0.52, 0.59) | 0.54 (0.52, 0.57) | 0.59 (0.55, 0.63) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.109 (0.062, 0.157) | 0 (0, 0) | 0.025 (0.005, 0.046) | 0.041 (0.041, 0.041) | 0.028 (0.006, 0.051) | 0.035 (0.007, 0.062) | 0.085 (0.082, 0.089) | 0.054 (0.05, 0.058) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Taxel_therapies | count | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 | 96 |
| time | 28 (17, 35) | 28 (17, 35) | 28 (17, 35) | 28 (17, 35) | 28 (17, 35) | 28 (17, 35) | 28 (17, 35) | 28 (17, 35) | 28 (17, 35) | 28 (17, 35) | 28 (17, 35) | 28 (17, 35) | 28 (17, 35) | 28 (17, 35) | 28 (17, 35) | 28 (17, 35) | ||
| n | 16 (6, 36) | 6 (2, 12) | 11 (5, 27) | 10 (5, 28) | 4 (1, 11) | 4 (0, 12) | 3 (0, 8) | 2 (0, 6) | 6 (3, 16) | 5 (2, 10) | 6 (2, 12) | 5 (2, 10) | 3 (1, 7) | 3 (1, 7) | 3 (0, 8) | 2 (0, 6) | ||
| post_p | 0.12 (0.02, 0.33) | 0.25 (0.12, 0.45) | 0.19 (0.07, 0.44) | 0.19 (0.04, 0.42) | 0.27 (0.15, 0.47) | 0.28 (0.1, 0.45) | 0.32 (0.18, 0.48) | 0.3 (0.17, 0.46) | 0.29 (0.09, 0.45) | 0.28 (0.13, 0.44) | 0.27 (0.13, 0.46) | 0.27 (0.14, 0.45) | 0.35 (0.17, 0.45) | 0.32 (0.17, 0.46) | 0.33 (0.14, 0.46) | 0.34 (0.2, 0.47) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.122 (0.085, 0.213) | 0.135 (0.083, 0.3) | 0.122 (0.091, 0.198) | 0.124 (0.089, 0.199) | 0.156 (0.085, 0.456) | 0.164 (0.09, 0.366) | 0.148 (0.081, 0.358) | 0.157 (0.095, 0.7) | 0.137 (0.087, 0.275) | 0.141 (0.082, 0.341) | 0.13 (0.083, 0.267) | 0.141 (0.088, 0.318) | 0.157 (0.09, 0.453) | 0.165 (0.084, 0.562) | 0.155 (0.081, 0.487) | 0.145 (0.083, 0.482) | ||
| Carboplatin | count | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | |
| time | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | ||
| n | 18 (8, 51) | 4 (2, 13) | 11 (5, 43) | 8 (3, 22) | 6 (2, 15) | 6 (2, 15) | 4 (1, 9) | 3 (1, 8) | 4 (2, 10) | 3 (1, 8) | 4 (1, 12) | 4 (1, 10) | 4 (1, 8) | 4 (1, 8) | 4 (1, 10) | 4 (1, 10) | ||
| post_p | 0.11 (0.02, 0.34) | 0.29 (0.13, 0.45) | 0.21 (0.06, 0.36) | 0.24 (0.06, 0.4) | 0.31 (0.12, 0.45) | 0.31 (0.09, 0.46) | 0.3 (0.18, 0.44) | 0.31 (0.17, 0.42) | 0.27 (0.11, 0.42) | 0.32 (0.18, 0.45) | 0.31 (0.11, 0.46) | 0.28 (0.14, 0.43) | 0.33 (0.17, 0.48) | 0.3 (0.09, 0.47) | 0.29 (0.18, 0.45) | 0.32 (0.1, 0.47) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.117 (0.086, 0.16) | 0.149 (0.082, 0.51) | 0.122 (0.09, 0.194) | 0.126 (0.089, 0.374) | 0.133 (0.087, 0.554) | 0.135 (0.089, 0.311) | 0.149 (0.093, 0.314) | 0.178 (0.094, 0.456) | 0.146 (0.102, 0.476) | 0.14 (0.084, 0.452) | 0.136 (0.084, 0.336) | 0.168 (0.099, 0.608) | 0.142 (0.097, 0.634) | 0.144 (0.095, 0.492) | 0.134 (0.084, 0.479) | 0.144 (0.09, 0.5) | ||
| Niraparib | count | 77 | 77 | 77 | 77 | 77 | 77 | 77 | 77 | 77 | 77 | 77 | 77 | 77 | 77 | 77 | 77 | |
| time | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | 30 (20, 35) | ||
| n | 20 (8, 57) | 5 (1, 13) | 11 (4, 40) | 7 (4, 21) | 6 (3, 12) | 6 (3, 14) | 4 (2, 9) | 4 (1, 8) | 5 (2, 12) | 4 (1, 8) | 4 (1, 12) | 3 (1, 8) | 4 (1, 8) | 3 (1, 8) | 4 (2, 8) | 4 (2, 7) | ||
| post_p | 0.1 (0.01, 0.29) | 0.32 (0.14, 0.47) | 0.17 (0.06, 0.4) | 0.24 (0.1, 0.45) | 0.31 (0.13, 0.47) | 0.24 (0.12, 0.44) | 0.31 (0.16, 0.47) | 0.29 (0.13, 0.44) | 0.29 (0.12, 0.47) | 0.29 (0.16, 0.47) | 0.32 (0.14, 0.44) | 0.32 (0.11, 0.45) | 0.31 (0.14, 0.46) | 0.3 (0.17, 0.48) | 0.32 (0.17, 0.46) | 0.3 (0.16, 0.43) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.119 (0.094, 0.172) | 0.123 (0.082, 0.604) | 0.118 (0.086, 0.266) | 0.117 (0.076, 0.255) | 0.125 (0.087, 0.215) | 0.143 (0.087, 0.311) | 0.139 (0.09, 0.405) | 0.148 (0.095, 0.453) | 0.134 (0.081, 0.374) | 0.16 (0.09, 0.658) | 0.152 (0.089, 0.354) | 0.145 (0.09, 0.527) | 0.162 (0.098, 0.393) | 0.179 (0.104, 0.438) | 0.127 (0.085, 0.342) | 0.145 (0.094, 0.455) | ||
| TP53- & AR- | Hormone_therapies | count | 1 | 1 | 1 | 1 | ||||||||||||
| time | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | 6 (6, 6) | ||||||||||||||
| n | 22 (22, 22) | 3 (3, 3) | 1 (1, 1) | 0 (0, 0) | ||||||||||||||
| post_p | 0.36 (0.36, 0.36) | 0.16 (0.16, 0.16) | 0.44 (0.44, 0.44) | NA (NA, NA) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.078 (0.078, 0.078) | 0.284 (0.284, 0.284) | 0 (0, 0) | NA (NA, NA) | ||||||||||||||
| Taxel_therapies | count | 383 | 383 | 383 | 383 | |||||||||||||
| time | 21 (13, 31) | 21 (13, 31) | 21 (13, 31) | 21 (13, 31) | ||||||||||||||
| n | 19 (10, 55) | 6 (2, 15) | 5 (2, 14) | 5 (2, 14) | ||||||||||||||
| post_p | 0.16 (0.02, 0.43) | 0.33 (0.13, 0.47) | 0.32 (0.15, 0.47) | 0.36 (0.16, 0.47) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.117 (0.086, 0.18) | 0.123 (0.08, 0.299) | 0.145 (0.083, 0.429) | 0.132 (0.078, 0.422) | ||||||||||||||
| Carboplatin | count | 396 | 396 | 396 | 396 | |||||||||||||
| time | 20 (13, 31) | 20 (13, 31) | 20 (13, 31) | 20 (13, 31) | ||||||||||||||
| n | 20 (8, 66) | 5 (2, 13) | 7 (3, 15) | 6 (2, 15) | ||||||||||||||
| post_p | 0.18 (0.02, 0.44) | 0.34 (0.16, 0.48) | 0.34 (0.15, 0.48) | 0.33 (0.11, 0.48) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.114 (0.085, 0.182) | 0.129 (0.075, 0.345) | 0.121 (0.082, 0.33) | 0.135 (0.081, 0.326) | ||||||||||||||
| Niraparib | count | 402 | 402 | 402 | 402 | |||||||||||||
| time | 19 (13, 32) | 19 (13, 32) | 19 (13, 32) | 19 (13, 32) | ||||||||||||||
| n | 18 (8, 55) | 5 (2, 13) | 7 (3, 15) | 6 (3, 13) | ||||||||||||||
| post_p | 0.21 (0.03, 0.43) | 0.35 (0.16, 0.48) | 0.34 (0.13, 0.48) | 0.32 (0.12, 0.47) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.109 (0.083, 0.194) | 0.124 (0.077, 0.464) | 0.125 (0.085, 0.279) | 0.129 (0.085, 0.314) | ||||||||||||||
| TP53+ | Taxel_therapies | count | 263 | 263 | 263 | 263 | 263 | 263 | 263 | 263 | ||||||||
| time | 24 (12, 33) | 24 (12, 33) | 24 (12, 33) | 24 (12, 33) | 24 (12, 33) | 24 (12, 33) | 24 (12, 33) | 24 (12, 33) | ||||||||||
| n | 12 (5, 33) | 11 (6, 27) | 3 (1, 8) | 3 (1, 8) | 5 (2, 14) | 5 (2, 11) | 3 (1, 8) | 3 (0, 8) | ||||||||||
| post_p | 0.19 (0.05, 0.43) | 0.19 (0.04, 0.43) | 0.35 (0.18, 0.48) | 0.37 (0.21, 0.48) | 0.3 (0.13, 0.46) | 0.32 (0.14, 0.48) | 0.35 (0.18, 0.48) | 0.35 (0.18, 0.47) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.121 (0.083, 0.217) | 0.124 (0.086, 0.216) | 0.157 (0.077, 0.491) | 0.143 (0.082, 0.526) | 0.134 (0.084, 0.345) | 0.135 (0.085, 0.296) | 0.149 (0.071, 0.769) | 0.155 (0.084, 0.602) | ||||||||||
| Carboplatin | count | 231 | 231 | 231 | 231 | 231 | 231 | 231 | 231 | |||||||||
| time | 26 (14, 34) | 26 (14, 34) | 26 (14, 34) | 26 (14, 34) | 26 (14, 34) | 26 (14, 34) | 26 (14, 34) | 26 (14, 34) | ||||||||||
| n | 12 (5, 40) | 9 (3, 27) | 4 (1, 10) | 4 (1, 10) | 4 (1, 13) | 4 (1, 13) | 4 (1, 9) | 4 (2, 10) | ||||||||||
| post_p | 0.19 (0.03, 0.43) | 0.23 (0.06, 0.45) | 0.32 (0.16, 0.46) | 0.33 (0.17, 0.47) | 0.33 (0.16, 0.47) | 0.33 (0.14, 0.47) | 0.34 (0.17, 0.47) | 0.33 (0.16, 0.48) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.122 (0.086, 0.23) | 0.129 (0.087, 0.298) | 0.141 (0.085, 0.366) | 0.149 (0.08, 0.465) | 0.136 (0.085, 0.43) | 0.133 (0.082, 0.413) | 0.139 (0.085, 0.415) | 0.134 (0.078, 0.425) | ||||||||||
| Niraparib | count | 225 | 225 | 225 | 225 | 225 | 225 | 225 | 225 | |||||||||
| time | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | 24 (14, 34) | ||||||||||
| n | 11 (5, 40) | 8 (3, 24) | 4 (2, 10) | 4 (1, 9) | 4 (1, 11) | 4 (1, 11) | 4 (1, 9) | 4 (2, 9) | ||||||||||
| post_p | 0.22 (0.05, 0.44) | 0.23 (0.08, 0.46) | 0.34 (0.16, 0.48) | 0.32 (0.16, 0.47) | 0.35 (0.17, 0.48) | 0.34 (0.15, 0.47) | 0.33 (0.15, 0.47) | 0.33 (0.18, 0.47) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.115 (0.084, 0.239) | 0.121 (0.086, 0.288) | 0.137 (0.079, 0.383) | 0.146 (0.081, 0.461) | 0.138 (0.076, 0.357) | 0.138 (0.079, 0.381) | 0.143 (0.082, 0.454) | 0.138 (0.085, 0.374) | ||||||||||
| DRD+ | Taxel_therapies | count | 137 | 137 | 137 | 137 | 137 | 137 | 137 | 137 | ||||||||
| time | 27 (20, 34) | 27 (20, 34) | 27 (20, 34) | 27 (20, 34) | 27 (20, 34) | 27 (20, 34) | 27 (20, 34) | 27 (20, 34) | ||||||||||
| n | 5 (2, 13) | 5 (2, 13) | 3 (1, 9) | 3 (1, 7) | 3 (1, 8) | 3 (1, 9) | 4 (1, 9) | 3 (1, 8) | ||||||||||
| post_p | 0.3 (0.12, 0.47) | 0.3 (0.12, 0.46) | 0.33 (0.18, 0.48) | 0.35 (0.19, 0.48) | 0.36 (0.17, 0.46) | 0.32 (0.18, 0.46) | 0.34 (0.18, 0.46) | 0.34 (0.19, 0.47) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.151 (0.083, 0.4) | 0.142 (0.081, 0.383) | 0.149 (0.083, 0.48) | 0.139 (0.087, 0.516) | 0.15 (0.091, 0.395) | 0.154 (0.087, 0.444) | 0.141 (0.087, 0.649) | 0.15 (0.081, 0.468) | ||||||||||
| Carboplatin | count | 199 | 199 | 199 | 199 | 199 | 199 | 199 | 199 | |||||||||
| time | 25 (17, 34) | 25 (17, 34) | 25 (17, 34) | 25 (17, 34) | 25 (17, 34) | 25 (17, 34) | 25 (17, 34) | 25 (17, 34) | ||||||||||
| n | 6 (2, 15) | 6 (2, 15) | 5 (2, 10) | 4 (1, 9) | 4 (1, 9) | 4 (1, 10) | 4 (1, 9) | 4 (2, 10) | ||||||||||
| post_p | 0.32 (0.12, 0.47) | 0.27 (0.11, 0.47) | 0.33 (0.16, 0.47) | 0.34 (0.15, 0.46) | 0.33 (0.15, 0.47) | 0.35 (0.13, 0.47) | 0.34 (0.16, 0.47) | 0.32 (0.14, 0.48) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.122 (0.083, 0.327) | 0.134 (0.088, 0.311) | 0.141 (0.093, 0.351) | 0.157 (0.085, 0.388) | 0.14 (0.087, 0.452) | 0.134 (0.084, 0.398) | 0.138 (0.08, 0.431) | 0.144 (0.087, 0.43) | ||||||||||
| Niraparib | count | 182 | 182 | 182 | 182 | 182 | 182 | 182 | 182 | |||||||||
| time | 26 (16, 34) | 26 (16, 34) | 26 (16, 34) | 26 (16, 34) | 26 (16, 34) | 26 (16, 34) | 26 (16, 34) | 26 (16, 34) | ||||||||||
| n | 7 (3, 15) | 6 (3, 14) | 4 (2, 10) | 4 (1, 10) | 4 (1, 9) | 4 (1, 10) | 4 (1, 10) | 4 (2, 9) | ||||||||||
| post_p | 0.3 (0.11, 0.47) | 0.31 (0.12, 0.45) | 0.31 (0.16, 0.46) | 0.3 (0.18, 0.48) | 0.31 (0.15, 0.47) | 0.32 (0.15, 0.48) | 0.34 (0.16, 0.45) | 0.34 (0.17, 0.47) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.129 (0.085, 0.244) | 0.127 (0.09, 0.281) | 0.146 (0.089, 0.404) | 0.143 (0.083, 0.461) | 0.158 (0.097, 0.394) | 0.153 (0.088, 0.378) | 0.145 (0.085, 0.454) | 0.145 (0.085, 0.362) | ||||||||||
| TEfus+ | Taxel_therapies | count | 224 | 224 | 224 | 224 | 224 | 224 | 224 | 224 | ||||||||
| time | 23 (15, 33) | 23 (15, 33) | 23 (15, 33) | 23 (15, 33) | 23 (15, 33) | 23 (15, 33) | 23 (15, 33) | 23 (15, 33) | ||||||||||
| n | 5 (2, 12) | 11 (6, 29) | 4 (1, 13) | 3 (1, 7) | 5 (2, 12) | 5 (2, 11) | 3 (1, 8) | 3 (1, 7) | ||||||||||
| post_p | 0.29 (0.12, 0.45) | 0.2 (0.04, 0.45) | 0.33 (0.13, 0.46) | 0.34 (0.19, 0.46) | 0.3 (0.13, 0.46) | 0.32 (0.13, 0.47) | 0.35 (0.17, 0.46) | 0.35 (0.17, 0.48) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.138 (0.087, 0.341) | 0.123 (0.089, 0.201) | 0.144 (0.081, 0.446) | 0.148 (0.085, 0.577) | 0.138 (0.086, 0.354) | 0.132 (0.086, 0.3) | 0.154 (0.082, 0.487) | 0.155 (0.082, 0.544) | ||||||||||
| Carboplatin | count | 203 | 203 | 203 | 203 | 203 | 203 | 203 | 203 | |||||||||
| time | 26 (15, 33) | 26 (15, 33) | 26 (15, 33) | 26 (15, 33) | 26 (15, 33) | 26 (15, 33) | 26 (15, 33) | 26 (15, 33) | ||||||||||
| n | 5 (2, 13) | 9 (3, 25) | 6 (2, 15) | 4 (1, 9) | 4 (1, 11) | 4 (1, 13) | 4 (2, 10) | 4 (2, 10) | ||||||||||
| post_p | 0.32 (0.14, 0.47) | 0.24 (0.07, 0.43) | 0.3 (0.09, 0.46) | 0.31 (0.14, 0.45) | 0.31 (0.17, 0.47) | 0.33 (0.15, 0.47) | 0.32 (0.13, 0.47) | 0.33 (0.14, 0.46) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.132 (0.078, 0.358) | 0.121 (0.088, 0.291) | 0.131 (0.086, 0.307) | 0.152 (0.082, 0.496) | 0.138 (0.08, 0.423) | 0.137 (0.087, 0.397) | 0.136 (0.087, 0.443) | 0.135 (0.085, 0.433) | ||||||||||
| Niraparib | count | 231 | 231 | 231 | 231 | 231 | 231 | 231 | 231 | |||||||||
| time | 26 (16, 34) | 26 (16, 34) | 26 (16, 34) | 26 (16, 34) | 26 (16, 34) | 26 (16, 34) | 26 (16, 34) | 26 (16, 34) | ||||||||||
| n | 4 (2, 13) | 9 (3, 25) | 7 (3, 15) | 4 (1, 9) | 4 (1, 9) | 4 (1, 10) | 4 (1, 10) | 4 (2, 10) | ||||||||||
| post_p | 0.33 (0.12, 0.47) | 0.23 (0.09, 0.45) | 0.3 (0.12, 0.46) | 0.33 (0.14, 0.47) | 0.33 (0.15, 0.47) | 0.34 (0.15, 0.46) | 0.31 (0.15, 0.47) | 0.32 (0.16, 0.47) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.133 (0.084, 0.419) | 0.121 (0.085, 0.29) | 0.134 (0.087, 0.298) | 0.145 (0.086, 0.45) | 0.147 (0.083, 0.594) | 0.14 (0.084, 0.386) | 0.14 (0.081, 0.408) | 0.139 (0.087, 0.339) |